Just like with natural teeth, if the plaque biofilm is allowed to accumulate on implants, peri-implant mucositis occurs, which can subsequently develop into peri-implantitis, characterized by peri-implant bone destruction and even implant loss. This new 3D movie visualizes the intercellular processes that are involved as peri-implant tissue transitions from health to mucositis, from mucositis to peri-implantitis, and finally back to health. This sophisticated HD animation successfully conveys the essentials of cell-to-cell communication, visualizing the invisible yet fascinating world of signals and signaling within the human body.